Genomic Enterprise

 

Costa FF. (September, 2022) Interviewed by the news channel "California Today" on Apple's products release. 

 

Costa FF. (June, 2021) Videocast on YouTube & Podcast on Spotify to the Founders & Business Podcast hosted by Ayman Elyasin.

 

Costa FF. (February, 2021) Podcast on Transforming Data into Results. Episode 23. Billionaires In Boxers Global hosted by Phil Pelucha.

 

Costa FF. (January, 2021) Podcast on Exploring the Science of Data. Episode 26. Half Time Orange hosted by Brenton Webber.

 

Costa FF. (August, 2020). Podcast on Entrepreneurship, Leadership & Science Communication. When Science Speaks hosted by Mark Bayer.

 

Leite ML, Brito N, Costa FF. (July, 2020) Epigenomic tools under development for cancer management. Cancer Management & Research. In press.

 

Leite ML, Costa LSL, Cunha VA, Kreniski V,  Filho MOB, da Cunha NB, Costa FF. (May, 2020) Artificial Intelligence (AI) and the Future of Biomedicine. Drug Discovery Today. (Selected to be the cover of the Issue!)

 

Costa FF. et al. (January, 2020) Antitumoral activity of liraglutide, a new DNMT inhibitor in breast cancer cells in vitro and in vivo. Chemico-Biological Interactions. In press.

 

Leite ML, Cunha MB, Costa FF. (December, 2019) Epigenetic Therapies in the Precision Medicine Era. Advanced Therapeutics. Vol. 3, Issue 8, 2020 (Selected to be the Cover of the Issue!)

 

Malard PF, Brunel HSS, Dallago BSL, Costa FF, Peixer M (April, 2018) Effect of Mesenchymal Stem Cells (MSCs) on Corneal Wound Healing in Dogs. Journal of Tradicional and Complementary Medicine. In press.



Personal Interview  to the Magazine  VoyageChicago about GenomeConnect startup's mission and vision (December, 2017)

 

Nicola AM, Costa FF, Felipe MS (November, 2017) Antifungal Drugs: new insights in Research & Development. Pharmacology & Therapeutics. In press.

 

Cunha NB, Leite ML,  Sampaio KB,  Costa FF, Franco OL & Dias SC (October, 2017) Molecular farming of antimicrobial peptides: available platforms and strategies for improving protein biosynthesis using modified virus vectors. Annals of the Brazilian Academy of Sciences. In press.



Leite ML & Costa FF (October, 2017) Epigenomics, Epigenetics and Cancer. Rev Pan-Amaz Saude. In press.



Klassen, LMB,  Chequin A, Manica GCM, Biembengut IV,  Toledo, MB,  Baura, V,  Pedrosa, FO,  Ramos, ES, Costa FF, Souza EM, Klassen G. (August, 2017) MMP9 Gene Expression Regulation by Intragenic Epigenetic Modifications in Breast Cancer. Gene. In press.

 

Vanin EF, Leite ML, Iannaccone S, Bischof JM, Passetti F, Alencar S, Costa FF (July, 2017) Transcriptome Analysis and Gene Networks in a Rare Pediatric Tumor. Biotechnology Research and Innovation. In press.

 

Pogue R, Cavalcanti DP, Shanker S, Andrade RV, Aguiar LR, de Carvalho JL, Costa FF. (May, 2017) Rare Genetic Diseases: Update on Diagnosis, Treatment and Online Resources. Drug Discovery Today. In press.



Interview about Entrepreneurship Culture, Innovation and StartUps in the Academic Sector (in Portuguese) for a Brazilian Newspaper from the Capital of Brazil, Brasilia, "Correio Braziliense" (December, 2016).

 

Leite ML, Cunha NB & Costa FF (December, 2016). Antimicrobial Peptides, Nanotechnology, and Natural Metabolites as Novel Approaches for Cancer Treatment. Pharmacology & Therapeutics. In press.

 

de Oliveira MS, Goes AM, Costa FF, Carvalho JL (December, 2016). Stem cells and Cardiovascular Diseases: turning bad days into good ones? Drug Discovery Today. In press.

 

Costa FF. Participation on the Event in Portuguese "Pharmaceutical Innovation and Intellectual Property (IP)" promoted by the National Academy of Pharmacy in Brazil (August, 2016)

 

Manica GCM, Ribeiro CF, de Oliveira MAS, Pereira IT, Chequin A, Ramos EAS, Klassen LMB,  Sebastião APM, Alvarenga LM, Zanata SM, De Noronha L, Rabinovich I, Costa FF, Souza EM, Klassen G (July, 2016). Downregulation of ADAM33 as a Predictive Biomarker of Aggressive Breast Cancer. Scientific Reports. In press.

 

Shidfar A, Wang J, Costa FF, Scholtens D, Bischof JM, Sullivan ME,Ivancic DZ, Vanin EF (In Memoriam), Soares MB, Khan SA (June, 2016). Expression of miR-18a and miR-210 in normal breast tissue as candidate biomarkers for breast cancer risk. Cancer Prevention Research. In press.



Samis J, Vanin EF (In Memoriam), Sredni ST, Bonaldo MF, Costa FF, Habiby R, Zimmerman D and Soares MB. (March, 2016) Extensive miRNA Expression Analysis in Craniopharyngiomas. Child's Nervous System. In press.

 

Cunha NB, Viana JFC, Lima LA, Cobacho NB, Sampaio, KBO, Dohms SM, Costa FF, Mulder K, Cardoso AG, Oliveira R, Ferreira ACR, Franco OL & Dias  SC. (January, 2016) Next Generation of Antimicrobial Peptides (AMPs) as molecular therapeutic tools for the treatment of diseases with social and economical impact. Drug Discovery Today. In press.

 

Silva DOF, Azevedo ARS, Lawall ARN, Figueiredo IR, de Carvalho LAD, de Castro UR & Costa FF (December, 2015) Pharmacodermia Induced by Bupropion in a Patient with Major Depressive Disorder: does pharmacogenomics play a role? Journal of Psychopharmacology. In press.



Interview in Portuguese about DataGenno and Elsevier's Partnership to the Portal SaudeBusiness (November, 2015).

 

Ribeiro SM, Felício MR, Vilas-Boas E, Gonçalves S, Costa FF, Samy RP, Santos NC, Franco OL (November, 2015)  New Frontiers for Anti-Biofilm Drug Development. Pharmacology & Therapeutics. In press.



Ramos EAS, Silva CT, Manica GCM, Pereira IT, Klassen LMB, Prado KB, Ribeiro EMS, Cavalli IJ,  Lima RS, Urban AC, Costa FF, Noronha L, Klassen G. (August, 2015) Worse Prognosis in Breast Cancer Patients can be Predicted by Immunohistochemical Analyses of Positive MMP-2 and Negative Estrogen and Progesterone Receptors. Rev. Ass. Med. Bras. In press.



Junior NGO, Fernandes GR, Costa FF, Cardoso MH, Candido ES, Neto DG, Mortari MR, Schwartz EF,  Franco OL & Alencar SA (July, 2015) Venom Gland Transcriptome analyses of two freshwater stingrays from Brazil. Scientific Reports. In press.

 

Hamm, CA,  Costa, FF, Bischof, JM, Vanin EF, Bonaldo, MD,  Iannaccone, S, Rajaram, V,  George, D, Tomita, T,  Goldman, S, Jennings, LJ, Gilbertson, RJ,  Soares, MB. (October, 2014) Identification of genes that frequently exhibit copy number alterations in pediatric ependymomas. Cancer Research. v74, 19, p3111.

 

DataGenno mentioned in the eBook in Portuguese about Entrepreunership in Health (June, 2014).

 

Pereira IT, Ramos EAS, Costa ET,  Camargo AA, Manica GCM, Klassen LMB, Chequin A, Braun-Prado K, Pedrosa F, Souza EM, Costa FF, Klassen G (November, 2013) Fibronectin Affects Transient MMP2 Gene Expression through DNA Demethylation Changes in Non-Invasive Breast Cancer Cell Lines. PLoS ONE. In press.

 

Tavares R, Scherer N, Ferreira CG, Costa FF & Passetti F (November, 2013)  Splice variants in the proteome: a promising and challenging field to targeted drug discovery. Drug Discovery Today. In press.

 

Costa FF From 1,200 to 14: StartUp Health’s new class get pass into special 3-year program. Selected CEO for the 3 year StartUp Health academy “MBA” Program. StartUp Health's academy program is long-term, highly structured, and is designed to help startups become sustainable businesses. Venture Beat, 2013.

 

McErlean P, Favoreto Jr S, Costa FF , Shen J, Quarishi J, Biyasheva A, Cooper JJ, Scholtens DM, Vanin EF, Bonaldo MF, Xie H, Soares MB, Avila PC (August, 2013) Human rhinovirus infection causes different DNA methylation changes in nasal epithelial cells from healthy and asthmatic subjects. BMC Medical Genomics. In press.

 

Machado CML, Andrade LNS, Teixeira VR, Costa FF, Melo CM, Santos S, Nonogaki S, Liu F, Bernardes ES, Camargo AA, Chammas R. (July, 2013) Galectin-3 disruption impaired tumoral angiogenesis by reduction of VEGF secretion from macrophages induced by TGFb1. Cancer Medicine. In press.

 

Estefan JL, Queiroz M, Costa FF, Coutinho MP, Higino K, Llerena JC, Vargas FR, Santos S, Geller M, Ribeiro MG. (June, 2013) Clinical Characteristics of Alopecia Areata in Down Syndrome. Acta Dermatovenerologica. In press.

 

Gujarathi R & Costa FF (June, 2013) The impact of online networks and big data in Life Sciences. Social Networking. In press.

 

Xu D, Huang CC, Kachaochana A, Morgan GA, Bonaldo MF, Soares MB, Costa FF, Sarwark J, Sredni ST, Pachman LM. (March, 2013) MicroRNA-10a Regulation of Proinflammatory Mediators: An Important Component of Untreated Juvenile Dermatomyositis. The Journal of Rheumatology. 43 (1): 161-168.

 

Costa FF (January, 2013). Big Data In Biomedicine. Drug Discovery Today. In press.

 

Hamm C & Costa FF (December, 2012). Epigenomes as Therapeutic Targets. Pharmacology and Therapeutics. In press.

 

Costa FF (October, 2012). Big Data in Genomics: Challenges and Solutions. G.I.T. Laboratory (Featured in the Cover of the Issue) In press.

Check the German Version of this article here!

 

Manica GCM, Ramos EAS, de Oliveira MAS, Costa FF, Pedrosa FO, de Souza EM, de Noronha L, Klassen G (September, 2012). ADAM33 as a new biomarker for invasive lobular breast carcinoma. Journal of Cancer Science and Therapy. In press.

 

Klassen G & Costa FF (August, 2012). Non-coding RNAs: more questions than answers. Journal of Cancer Science and Therapy. In press.

 

Costa FF (June, 2012). Social Networks, Web-based Tools and Diseases: implications for biomedical research. Drug Discovery Today (Cover of the Issue) In press.

 

Lin X, Rice KL, Buzzai M, Hexner E, Costa FF, Kilpivaara O, Mullally A, Soares MB, Ebert BL, Levine R and Licht JD. (June, 2012). miR-433 Is Aberrantly Expressed In Myeloproliferative Neoplasms And Suppresses Hematopoietic Cell Growth And Differentiation. Leukemia. In press.

 

Martin J, Bryar P, Mets M, Weinstein J, Jones A, Vanin EF, Scholtens D, Costa FF, Soares MB, Laurie NA. (May, 2012). Differentially Expressed miRNAs in Retinoblastoma. Gene. In press.

 

Mota AJ, Burggemann S, Costa FF (March, 2012). MODY 2: Mutation Identification and Molecular Ancestry in a Brazilian Family. Gene. In press.

 

Costa FF (December, 2011) Basic research, applied medicine and EHRs - are we on the right track? Journal of Cancer Science and Therapy. In press.

 

Ramos EAS, Grochoski M, Braun-Prado K, Seniski G, Cavalli I, Ribeiro EMSF, Camargo AA, Costa FF, Klassen G (November, 2011). Epigenetic changes of CXCR4 and its ligand CXCL12 as prognostic factors for sporadic breast cancer. PLoS ONE. In press.

 

Interviewed for a Feature article about Brazilian scientific rise and the economic crisis in the USA. Petherick A (October, 2011). Brazilians lured back home with research funding and stability. Nature Medicine (17) : 1173.

 

Costa FF, Bischof JM, Vanin EF, Lulla RR, Wang M, Sredni ST, Rajaram V, Bonaldo MF, Wang D, Goldman S, Tomita T, Soares MB. (July, 2011). Identification of microRNAs as potential prognostic markers in ependymoma. PLoS ONE. 6(10): e25114.

 

Coutinho MP & Costa FF (June, 2011). Social Media in Science and Medicine. G.I.T. Laboratory Journal. In press.

 

Lulla RR, Costa FF, Bischof JM, Chou PM, Bonaldo MF, Vanin EF, Soares MB (May, 2011). Identification of differentially expressed microRNAs in osteosarcoma. Sarcoma. In press.

 

Hamm C & Costa FF (May, 2011). The impact of epigenomics on future drug design and new therapies. Drug Discovery Today. In press.

 

Costa FF (April, 2011). Non-coding RNAs, epigenetics and complexity in human cells. Chapter for the Book Long Non-coding RNAs: Regulation of Gene expression and Drivers of Natural Selection - Horizon Scientific Press (Figure featured in the Cover) 2012.

Book Chapter featured in a Book Review and Comment at the Epigenetics Journal !

 

Costa FF, Foly LS, Coutinho MP (March, 2011). DataGenno: building a new tool to bridge molecular and clinical genetics. The Application of Clinical Genetics. Vol 4: 45-54.

 

Dr Costa was appointed as a member of the Editorial Board for the Journal of Cancer Science and Therapy

 

Molognoni F, Cruz AT, Meliso FM, Morais AS, Souza CF, Xander P, Bischof JM, Costa FF, Soares MB, Liang G, Jones PA, Jasiulionis MG (February, 2011).Epigenetic reprogramming as a key contributor to melanocyte malignant transformation. Epigenetics. (4):450-464.

 

Costa FF (October, 2010).Non-coding RNAs: could they be the answer? Briefings in Functional Genomics. In press.

 

Costa FF (October, 2010). Epigenomics in cancer management. Cancer Management and Research. Vol 2: 255 - 265.

 

Ichi S, Costa FF, Bischof JM, Nakazakia H, Shena YW, Boshnjakua V, Mania-Farnellc B, McLonea DG, Tomita T, Soares MB, Mayanil CSK (September, 2010). Folic acid remodels chromatin on Hes1 and Neurog2 promoters during caudal neural tube development. Journal of Biological Chemistry. 285: 36922-36932.

 

Berkofsky-Fessler W, Buzzai M, Kim MK, Fruchtman S,Najfeld V, Min DJ, Costa FF, Bischof JM, Soares MB, McConnell MJ, Zhang W, Levine R, Gilliland DG, Calogero R, Licht JD (July, 2010). Transcriptional profiling of Polycythemia Vera identifies gene expression patterns both dependent and independent from the action of JAK2V617F. Clinical Cancer Research. 6: 4339-4352.

 

Malchenko S, Galat V, Seftor E, Vanin EF, Costa FF, Seftor REB, Soares MB, Hendrix MJ (July, 2010).Cancer hallmarks in Induced Pluripotent Cells: new insights.Journal of Cellular Physiology. (Cover of the issue). 225: 390-393.

Our article in the NEWS: Science Daily and Lurie Cancer Center

 

Costa FF (July, 2010). Non-coding RNAs: Meet thy masters. Bioessays. 32 (7): 599-608 (Cover of the issue Photograph).

See the Issue of  "In Touch" covering the article on Bioessays here!

 

Mack GS & Marshall A (March, 2010). Interviewed and cited in a Feature article about cancer metastasis and drug development in the journal Nature Biotechnology entitled: "Lost in migration." Nat. Biotechnology. 28 (3): 214-229.

 

Costa FF (February, 2010). Non-coding RNAs: Old Molecules, new functions - Shifting paradigms in genomics? G.I.T. Laboratory Journal. Vol 8/9, 2010.

 

Sredni ST, Bonaldo MF, Costa FF, Chiang-Ching H, Hamm C, Rajaram V, Tomita T, Goldman S, Bischof JM, Soares MB (December, 2009). Upregulation of mir-221 and mir-222 in atypical teratoid/rhabdoid tumors: potential therapeutic targets. Childs Nervous System. 26, 279-283.

 

Costa FF (November, 2009). Genomics, epigenomics and personalized medicine - a bright future for drug development? BioForum Europe. Vol. 13, 29-31.

 

Hamm CA, Xie H, Costa FF, Vanin EF, Seftor EA, Sredni ST, Bischof JM, Bonaldo MF, Hendrix MJC, Soares MB. (December, 2009). Global demethylation of rat chondrosarcoma cells after treatment with 5-Aza-2-deoxycytidine results in increased tumorigenicity. PLoS ONE. 4 (12): e8340.

 

Ramos EAS, Camargo AA, Prado KB, Slowik R, Cavalli IJ, Ribeiro ESF, Pedrosa FO, Souza EM, Costa FF and Klassen G (October, 2009). Simultaneous CXCL12 and ESR1 CpG island hypermethylation correlates with poor prognosis in sporadic breast cancer. BMC Cancer. 10: 23.

 

Lewandowska MA, Costa FF, Bischof JM, Williams SH, Soares MB, Harris A (September, 2009). Multiple mechanisms influence regulation of the CFTR gene promoter. American Journal of Cell and Respiratory Biology.43 (3): 334-341.

 

Costa FF, Seftor EA, Bischof JM, Kirschmann DA, Strizzi L, Arndt K, Bonaldo MF, Soares MB, Hendrix MJ (December, 2009). Epigenetically Reprogramming Metastatic Tumor Cells with an Embryonic Microenvironment. Epigenomics. Vol. 1, 2: 387-398.

 

Lopes DO, Costa FF,  Goes AM, Canitrot Y, Hoffmann JS, Cazaux C, Franco GR, Macedo AM, Pena SD, Machado CR. (November, 2009). Isolation and characterization of HC1: a novel human DNA repair gene. Genet Mol Res. 8 (1): 247-260.

 

Strizzi L, Hardy KM, Seftor EA, Costa FF, Kirschman D, Seftor RE, Postovit LM, Hendrix MJ. (September, 2009). Development and cancer: at the crossroads of Nodal and Notch signaling. Cancer Research. 69: 7131-7134.

 

Verbisck NV, Costa ET, Costa FF, Cavalher FP, Costa MDM, Muras A, Paixo VA, Moura RP, Granato MF, Ierardi DF, Machado T, Melo F, Ribeiro KB, Cunha IW, Lima VCC, Maciel MS, Carvalho AL, Soares F, Zanata SM, Sogayar MC,Chammas R, Camargo AA (June, 2009). ADAM23 negatively modulates v3 integrin activation during metastasis. Cancer Research. 69: 5546-5552.

 

Costa FF (April, 2009). Non-coding RNAs and new opportunities for the private sector. Drug Discovery Today. 14 (9-10): 446 - 452.

Among the most downloaded from Drug Discovery Today!

 

Seniski GG, Camargo AA, Ierardi DF, Ramos EAS, Grochoski M, Ribeiro ESF, Cavalli IJ, Pedrosa FO, de Souza EM, Zanata SM,Costa FF and Klassen G (March, 2009). ADAM33 gene silencing by promoter hypermethylation as a molecular marker in breast invasive lobular carcinoma. BMC Cancer. 9 (1): 80.

 

Passetti F, Ferreira CG, Costa FF (February, 2009). The impact of microRNAs and alternative splicing in pharmacogenomics. Pharmacogenomics J. 9 (1): 1-13.

 

Maguire CA, Meijer DH, Leroy SG, Tierney LA, Broekman MLD, Costa FF, Breakefield XO, Stemmer-Rachamimov A, Sena-Esteves M (August, 2008) . Preventing growth of brain tumors by creating a zone of resistance. Molecular Therapy.16 (10):1695-1702.

See the Press Release about our article here!

 

Costa FF (February, 2008).Non-coding RNAs, epigenetics and complexity. Gene. 410 (1): 9-17.

 

Wurdinger T, Costa FF (November, 2007). An expert commentary entitled The potential of miRNA modulators as targeted oncology therapies - an update. Spectrum Newspaper for Pharmaceutical Industry Dynamics - Dealmaking and Financing: 15-26, 15-27.

 

Wurdinger T, Costa FF (October, 2007). Molecular therapy in the microRNA era. Pharmacogenomics J. 7(5):297-304.

 

Postovit LM, Costa FF, Bischof JM, Seftor EA, Wen B, Seftor RE, Feinberg AP, Soares MB, Hendrix MJ (July, 2007).The commonality of plasticity underlying multipotent tumor cells and embryonic stem cells. J Cell Biochem: 101(4):908-917.

 

Mack GS (June, 2007). Interviewed and cited in a feature article in the Nature Biotechnology Journal entitled MicroRNA gets down to business. Nat. Biotechnology. 25 (6):.631-638.

 

Wurdinger T, Costa FF (May, 2007). A spectrum expert commentary entitled The potential of miRNA modulators as targeted oncology therapies. Spectrum Newspaper for Pharmaceutical Industry Dynamics: 5-25.

 

Costa FF, Le Blanc K, Brodin B (March, 2007). Concise review: cancer/testis antigens, stem cells and cancer. Stem Cells: 25 (3):707-11.

Selected article for the cover of the issue!

 

Costa FF (January, 2007). Non-coding RNAs: lost in translation? Gene: 386 (1-2):1-10.

 

Costa FF, Paixo VA, Cavalher FP, Ribeiro KB, Cunha IW, Rinck JA, O'Hare M, Mackay A, Soares FA, Brentani RR, Camargo AA (March, 2006). SATR-1 hypomethylation is a common and early event in breast cancer. Cancer Genetics and Cytogenetics: 165 (2):135-143.

 

Costa FF (September, 2005). Non-coding RNAs: new players in eukaryotic biology.Gene: 357(2):83-94.

 

Costa FF (August, 2005). Non-coding RNAs: functional molecules or a quality control error? A comment on: BabaK T, Blencowe BJ and Hughes TR. A systematic search for new mammalian noncoding RNAs indicates little conserved intergenic transcription. BMC Genomics: 6: 104.

 

Costa FF, Colin C, Shinjo SM, Zanata SM, Marie SK, Sogayar MC, Camargo AA (June, 2005). ADAM23 methylation and expression analysis in brain tumors. Neuroscience Letters: 380 (3): 260-264.

 

Costa FF, Verbisck NV, Salim AC, Ierardi DF, Pires LC, Sasahara RM, Sogayar MC, Zanata SM, Mackay A, O'Hare M, Soares F, Simpson AJ, Camargo AA (February, 2004). Epigenetic silencing of the adhesion molecule ADAM23 is highly frequent in breast tumors. Oncogene: 23 (7):1481-1488.

 

Pres Release of an article in the News Magazine ISTOE from South America entitled "Hope Lives Here" about cancer research and its impact in Brazil (Published in 2003).

See the article online and the PDF file

 

Abrantes EF, Pires EG, Carvalho AF, Costa FF, Savino W, Reis LF (June, 2003). Identification, structural characterization and tissue distribution of Tsg-5: a new TNF-stimulated gene. Genes and Immunity: 4 (4):298-311.

 

Fabricio F. Costa and Anamaria A. Camargo (2003). Bases da Oncologia 2nd edition - Chapter 5: Oncogenes and Tumor Supressor Genes (Book Chapter).

 

Almeida-Silva S, Costa FF, Mares-Guia ML, Williams P, Melo MN (November, 1998). Lutzomyia longipalpis: pH in the gut, digestive glycosidases, and some speculations upon Leishmania development. Experimental Parasitology. 90 (3): 212-219.